By contributing to changes in metabolism, immunity, and neurophysiology, alterations in the gut microbiome influence developmental processes in the brain and are potentially involved in the development of Autism Spectrum Disorder.
Novel engineered nanoparticles have the ability to selectively deliver immune checkpoint blockade (ICB) therapy to tumors, allowing for targeted immunotherapy that is more efficient and has reduced side effects.
Chronic Adolescent Stress Found to Potentiate Sex-specific Immune Responses that May Contribute to Mood Disorders during Adulthood
Researchers from Emory University investigated whether chronic adolescent stress (CAS) modulates immune responses within the brain to promote depression and anxiety during adulthood and suggest that males and females are uniquely affected by CAS.
A novel Ebola vaccine demonstrates highly effective immunization against the virus, completely protecting all tested patients from infection, and is stable for long periods at refrigerator temperatures, marking a new milestone in the battle against this deadly disease.
New Insights into Tumor-Associated Monocytes and Macrophages Show Promise for the Treatment of Breast and Endometrial Cancers
The unique transcriptional profiles of tumor-associated macrophages and their progenitors, tumor-educated monocytes, have been used to develop diagnostic/prognostic gene signatures for breast and endometrial cancers and suggest potent therapeutic targets.
The presence of a white blood cell subpopulation was recently demonstrated to effectively distinguish individuals capable of naturally controlling HIV infection from people requiring antiviral medication.
A novel vaccine strategy combining two distinct viral vectors was demonstrated to induce a powerful immune response against the Hepatitis C Virus in mice.
A recent survey of Ulcerative Colitis patients and gastroenterologists in ten countries explored whether patients and physicians agree upon the importance of reasons for pursuing disease management.
Subcutaneous allergen immunotherapy has been demonstrated to be a safe and effective treatment for individuals allergic to a common fungus.
Genetic Variants of Receptor Detecting Inflammation and Tissue Damage May Increase Susceptibility for Depression
Genetic variants of an innate immune receptor that detects inflammation and tissue damage have been associated with HADS depression severity scores by a group of Hungarian researchers.