Novel engineered nanoparticles have the ability to selectively deliver immune checkpoint blockade (ICB) therapy to tumors, allowing for targeted immunotherapy that is more efficient and has reduced side effects.
New Insights into Tumor-Associated Monocytes and Macrophages Show Promise for the Treatment of Breast and Endometrial Cancers
The unique transcriptional profiles of tumor-associated macrophages and their progenitors, tumor-educated monocytes, have been used to develop diagnostic/prognostic gene signatures for breast and endometrial cancers and suggest potent therapeutic targets.
A therapy for steroid-refractory and/or resistant Graft-versus-Host-Disease may function by favorably altering a population of circulating white blood cells.
Possible Combination Treatment for Patients with Cancers not Responsive to Immune Checkpoint Inhibitors
The use of a drug stimulating an innate immune receptor could render immune checkpoint inhibitors functional in patients with otherwise unresponsive cancers.
CAR T Cells Show Efficacy for the Treatment of Relapsed and/or Refractory Aggressive Large B Cell Lymphoma
CAR T cells continue to show efficacy for the treatment of relapsed and/or refractory large B cell lymphoma.